Senna

Senna alexandrina

OTC stimulant laxative — FDA-approved for short-term constipation. Contains sennosides (anthraquinone glycosides). Works in 6-12 hours. SHORT-TERM USE ONLY (max 1-2 weeks). Chronic use causes melanosis coli and dependency.

Safety Profile

Contraindications

Pregnancy (debated — short-term likely OK). Bowel obstruction. IBD. Appendicitis. Dehydration.

Interactions

Heart meds (potassium depletion), diuretics, corticosteroids, digoxin.

Side Effects

Cramping, diarrhea, electrolyte imbalance. Melanosis coli with chronic use. Dependency.