Cinchona officinalis
Source of quinine — the original antimalarial drug. Discovery changed world history. Tonic water contains trace quinine. Historical use for fever, malaria, and leg cramps. Largely replaced by synthetic drugs.
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Heart medications (QT prolongation), blood thinners, diabetes meds, digoxin.
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Cardiac risk.
Cinchonism: tinnitus, headache, nausea, visual disturbances. Allergic thrombocytopenia.
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