Silybum marianum (standardized)
Standardized milk thistle extract — 80% silymarin (silybin A, silybin B, isosilybin A, isosilybin B, silychristin, silydianin). Hospital use for Amanita mushroom poisoning (IV silibinin). For liver protection, hepatitis, and cirrhosis support.
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CYP enzymes (variable), UGT enzymes, methotrexate, sirolimus.
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GI upset, headache, allergic reactions. Very safe overall.
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